Alterations of Lipid Profile Levels in 7,12-dimethylbenz(a)anthracene Induced Ulcerative Colitis Rat Model

Objective: Ulcerative colitis is a type of inflammatory bowel disease is a chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. We examined the lipid profile levels in murine model of 7,12-dimethylbenz(a)anthracene induced ulcerative colitis. Methods: Serum was separated from whole blood and was used to determine the lipid profile such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), free fatty acids, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C). Results: Ulcerative colitis rats exhibit a low level of LDL-C and TC. No significant difference was observed in HDL and TG, and significant difference was observed in PL and free fatty acid serum levels. This communication highlights the lipid profile that occurs in ulcerative colitis. Conclusion: This study, thus, provides valuable information about the disturbances in the lipids and lipoproteins occur in ulcerative colitis.